baker brothers life sciences

New York, NY, 10014. Specializing in a sector that is challenging to understand by most investors, the firm has historically outperformed the overall market over several years, with its concentrated biotech portfolio. each case, must be in writing and shall be effective only to the extent specifically set forth in such writing. Julian Baker and Felix Baker 's Baker Bros. Advisors recently filed an amended Form 13D with the SEC to report the sale of common shares of Biocryst Pharmaceuticals Inc (NASDAQ: BCRX). Other uncategorized cookies are those that are being analyzed and have not been classified into a category as yet. PitchBook helps you see a funds investments based on target industry, year and deal typeso you can quickly understand its strategy at a glance. (h)Series C Preferred means shares of the Companys Series C Preferred Stock, par value Brothers Julian and Felix Baker have earned their guru status on Wall Street, having delivered an exceptional track record of annualized returns over the years. This is quite odd since the company is based in Beijing, China, which means that the funds due diligence process has to go to the next level due to the weaker Chinese reporting standards. This Agreement shall automatically terminate upon the earliest of (i)such time as The stock currently trades at ~$344 and the stake is at 1.48% of the portfolio. Over the years, the firm had a number of home runs as the invested firms got acquired at huge premiums. You can also sign up for email updates on the SEC open data program, including best practices that make it more efficient to download data, and SEC.gov enhancements that may impact scripted downloading processes. The fund is located in New York, New York and will invest in United States. They add up to ~73% of the portfolio. closing of the IPO and for three (3)years thereafter, at any time at which the Investor and its Affiliates, collectively, beneficially own (i)the Required Shares and (ii)at least 2% of the Companys then-outstanding voting While the company has continued to grow, the business seems incapable of meeting investors past expectations. for so long as they remain in force, the Voting Agreement (as defined in the Purchase Agreement) and that certain letter agreement, dated as of January15, 2021, by and among the Company and the Investor, constitutes the full and entire Please include what you were doing when this page came up and the Cloudflare Ray ID found at the bottom of this page. That was followed with a ~45% stake increase in Q1 2017 at prices between ~$100 and ~$150. The parties hereto irrevocably submit, in any legal action or proceeding relating to They have a ~29% ownership stake in the business. This quarter also saw a minor ~4% trimming. Baker Brothers, a biotech investment firm, was founded by Julian & Felix Baker in 2000. Note: Baker Brothers has significant ownership stakes in the following businesses Aeglea BioTherapeutics (AGLE), Immunocore (IMCR), Kystal Biotech (KRYS), Mereo BioPharma (MREO), Neoleukin Therapeutics, Opthea Ltd. (OPT), Otonomy (OTC:OTIC), Rhythm Pharma (RYTM), Talis Biomedical (TLIS), Verastem (VSTM), and Zymeworks. These cookies help provide information on metrics the number of visitors, bounce rate, traffic source, etc. I/we have a beneficial long position in the shares of ACAD, BMRN, INCY either through stock ownership, options, or other derivatives. Since then the activity has been minor. value remained steady this quarter at $22.77B. Major activity in the last decade follows. Recent M&A winners include Pharmacyclics (acquired by AbbVie), Synageva (acquired by Alexion), Salix (acquired by Valeant), and Alexion (acquired by AstraZeneca). (f)Purchase Agreement. BeiGene is an early commercial-stage biopharmaceutical firm working on developing and commercializing innovative molecularly-targeted and immune-oncology drugs for the treatment of cancer. of such counsel, that such person would not be qualified to serve as a director of the Company under any applicable law (including requirements of fiduciary duties under applicable law), rule or regulation, rule of the stock exchange on which the Julian & Felix Baker also separately own ~550K additional shares. (i)Severability. The stock currently trades at ~$142. While the fund has made great gains since, the recent plunge has definitely compressed its unrealized gains, as the position was held stable once again. This Agreement shall be governed by and construed in accordancewith the internal Last significant activity was in Q4 2019 which saw a ~20% stake increase at prices between ~$14.50 and ~$76. Last major activity was in Q4 2018 when there was a ~40% stake increase at prices between ~$14 and ~$22. Edit Lists Featuring This Company Section. (d)Successors and Assigns. NEW YORK, NY address by providing the other party written notice of such change. Note: Baker Brothers controls ~10% of Madrigal Sciences. Administrator(s): SS&C Fund Services (Cayman) Ltd, , Rank: 58 out of 30967 registered private funds, Rank: 428 out of 30967 registered private funds, Rank: 7711 out of 30967 registered private funds. Baker Brothers controls ~16% of the business. Note: Baker Brothers controls ~5.5% of Amarin Corp. Seagen Inc. (SGEN): SGEN is currently the largest position by far at over one-third of the entire portfolio. Note that this policy may change as the SEC manages SEC.gov to ensure that the website performs efficiently and remains available to all users. Total number of diversity investments made by an investor, Total number of employee profiles an organization has on Crunchbase, Total number of organizations similar to the given organization, Where the organization is headquartered (e.g. It is still a very small position at 0.80% of the portfolio. These cookies track visitors across websites and collect information to provide customized ads. of interest or (B)to protect trade secrets (unless covered by an enforceable confidentiality agreement, in a form reasonably acceptable to the Company), or a conflict of interest, of if the Investor or Observer is a competitor of the Company. (j)Amendments and Waivers. Positions that are between 0.10% and 0.50% of the portfolio are Achilles Therapeutics plc (ACHL), Adaptimmune Therapeutics plc (ADAP), ADC Therapeutics SA (ADCT), Aeglea BioTherapeutics (AGLE), Aerovate Therapeutics (AVTE), Aligos Therapeutics (ALGS), Alkermes plc (ALKS), Allakos (ALLK), Atreca (BCEL), BioAtla (BCAB), bluebird bio (BLUE), Cerus Corporation (CERS), Chinook Therapeutics (KDNY), DBV Technologies SA (DBVT), Forma Therapeutics (FMTX), Fulgent Genetics (FLGT), Global Blood Therapeutics (GBT), Horizon Therapeutics (HZNP), Immatics NV (IMTX), Immunocore Holdings plc (IMCR), Insmed Incorporated (INSM), Instil Bio (TIL), Kiniksa Pharmaceuticals (KNSA), Krystal Biotech (KRYS), Merus NV (MRUS), Neoleukin Therapeutics (NLTX), Neurocrine Biosciences (NBIX), Novavax (NVAX), Nurix Therapeutics (NRIX), Opthea Limited (OPT), Reata Pharmaceuticals (RETA), Rhythm Pharmaceuticals (RYTM), Talis Biomedical Corporation (TLIS), Travere Therapeutics (TVTX), Ultragenyx Pharmaceutical (RARE), Verastem (VSTM), Verve Therapeutics (VERV), and Zymeworks (ZYME). This is crucial when investing in the biotech industry, as each company is very unique, requiring niche knowledge to understand its business model. After giving effect to the transactions reported herein and as a result of their ownership interest in Baker Brothers Life Sciences Capital (GP), LLC, Julian C. Baker and Felix J. Baker each may be deemed to have an indirect pecuniary interest in the Issuer's shares of Common Stock reported in column 5 of Table I directly held by Baker Brothers . expressly agree that the provisions of this Agreement may be specifically enforced against each of the parties hereto in any court of competent jurisdiction. Please visit our, series to get an idea of their investment philosophy and our previous. We reserve the right to block IP addresses that submit excessive requests. Fund structure AUM Fund type; Baker Brothers Investments: $25.71 bn: 667, L.P. $2.27 bn: Hedge Fund: Baker Brothers Life Sciences, L.P. $23.42 bn: Hedge Fund: Hcif Offshore LP: Latest filings (excl ownership) Julian has a business background from Harvard, while Felix has a Ph.D. in Immunology from Stanford. Notices shall be effective upon receipt. Shares started trading at ~$18 and currently goes for $27.21. H1 2018 saw the stake built from ~3.8M shares to ~12M shares at prices between ~$100 and ~$215. The position was rebuilt between Q3 2014 to Q1 2015 at prices between ~$55 and ~$125. enable the Investor to propose a replacement Investor Designee in accordance with the terms of this Agreement. This cookie is set by GDPR Cookie Consent plugin. This quarter saw a ~28% stake increase at prices between ~$113 and ~$177. Functional cookies help to perform certain functionalities like sharing the content of the website on social media platforms, collect feedbacks, and other third-party features. (a)Governing Law. Last major activity in MRTX was a ~50% selling in Q3 2019 at prices between ~$76 and ~$106. (c)Enforcement. Q2 & Q4 2020 saw a two-thirds stake increase at prices between ~$12.50 and ~$57.50. The current minimum investment for Baker Brothers Life Sciences, L.P. is $40000000. Baker Brothers Life Sciences, L.P. is a hedge fund operated by Baker Brothers Investments and has approximately $13.9 billion in assets. The stock is now well below that range at $9.78. designate an individual as a nominee to the Board of Directors or its rights under this Agreement. San Francisco Bay Area, Silicon Valley), Operating Status of Organization e.g. There are 20 positions that are significantly large (more than 0.5% of the portfolio each) and they are the focus of this article. Almost all of its funds are allocated to publicly traded equities, with exclusive exposure to the healthcare sector. Note: Baker Brothers controls ~13% of the business. Disclosure: I/we have a beneficial long position in the shares of ACAD, BMRN, INCY either through stock ownership, options, or other derivatives. Baker Bros. Advisors (GP) LLC (the "Adviser GP") is the Adviser's sole general partner. Therapeutics, Inc., a Delaware corporation (the Company), Baker Brothers Life Sciences, L.P. (BBLS) and 667, L.P. (667 and together with BBLS, the Investor). validity, legality and enforceability of the remaining provisions shall not in any way be affected or impaired thereby. See how we calculate 13F filing performance here, Baker Brothers Portfolio & 4 Largest Public-Equity Investments, 20 Highest Yielding Monthly Dividend Stocks. As a percentage of AUM, allocation to the highest conviction picks can be very high at over 30%. benefit of, and be binding upon, the successors, assigns, heirs, executors, and administrators of the parties hereto. EPS over the medium-term is expected to grow by around 30% since Incyte is an industry leader, having essentially monopolized its areas of treatment. Investors that are familiar with biotech companies are likely to find some hidden gems amongst their holdings. Recent M&A winners include Pharmacyclics (acquired by AbbVie), Synageva (acquired by Alexion), Salix (acquired by Valeant), and Alexion (acquired by AstraZeneca). The cookie is used to store the user consent for the cookies in the category "Performance". President, Rosenberg Ach Foundation. Contact Information Fund Manager Baker Brothers Investments Fund Category Section2(c), during the period beginning at the closing of the IPO until such time as the. The SEC defines Insiders as officers, directors, or significant investors (greater than 10% ownership) in a company. In . These cookies will be stored in your browser only with your consent. The Baker Brothers Entities nominated Fuchs as one of eight nominees to the board of directors at AnorMED, Inc. and, it can be inferred, given the timing, that Fuchs was also appointed by the Baker Brothers Entities to the Mirati Despite the uncertainty surrounding BeiGene, the company has developed into a fully integrated global biotechnology company with operations in China, the United States, Europe, and Australia. Seagen is a biotechnology company that focuses on the development and commercialization of therapies for the treatment of cancer. The position was built to ~20.5M shares in the 2004-2011 timeframe at prices between low-single-digits and low-20s. Incyte Corporation (INCY): INCY was already a 1.67M share stake in their first 13F filing in Q2 2003. (b)Notwithstanding the provisions of Section2(a), the Investor shall not be entitled to designate any Q3 2015 saw a ~30% stake increase at prices between ~$105 and ~$130. This Agreement may be executed in any number of counterparts (including by facsimile or Additionally, 100% of the funds holdings comprise companies operating in the healthcare sector. Kath Lavidge '74, P '09 - Chair. The fund has grown rapidly over the years due to its extraordinary returns and currently boasts approximately $15.2 billion of assets under management (AUM). Farah Champsi MBA '85. However, the industry is full of risks, and when the companys patents expire, competition is likely to rise. Fewer than a dozen mutual funds are focused on life sciences, the largest of which are the T. Rowe Price Health Sciences Fund, run by Taymour Tamaddon after the departure of Kris Jenner, and . Baker Brothers Life Sciences LP. Is this happening to you frequently? The stock currently trades at $3.46. Notices must be given: (a)by personal delivery, with receipt acknowledged; (b)by email followed by hard copy delivered by the methods (c)Bylaws means the Bylaws of the Company, as may be amended, restated or otherwise modified All text and design is copyright 2020 WhaleWisdom.com. to see more advanced email alert options such as selecting any type of Baker Brothers Life Sciences is based out of New York. Recent activity follows. Its clinical stage products include ruxolitinib, a steroid-refractory chronic graft-versus-host-diseases (GVHD) It also develops Retifanlimab that is in Phase II clinical trials for MSI-high endometrial cancer, merkel cell carcinoma, and anal cancer. We also use third-party cookies that help us analyze and understand how you use this website. Your IP: Q4 2018 saw a ~55% selling at prices between ~$9.50 and ~$15. Q1 2014 to Q1 2016 saw another stake doubling at prices between ~$30 and ~$55. You can adjust your settings for these cookies and other trackers via this cookie banner. The Company shall notify the Investor of any objection to an Investor Designee pursuant to this Section2(b) sufficiently in advance of the date Most recently, BioMarine got a positive CHMP opinion in Europe for ValRox for the treatment of Hemophilia type A. BioMarine has had a place in Baker Bros portfolio since Q2 2012. Felix Baker '91, PhD '98. This article is part of a series that provides an ongoing analysis of the changes made to Baker Brothers 13F stock portfolio on a quarterly basis. Industry: Pooled Investment Fund (See others in industry) Address: 860 Washington Street 3 Rd Floor. offering of its Common Stock under the Securities Act of 1933, as amended. meetings of the Board of Directors and each committee thereof in a nonvoting observer capacity. You also have the option to opt-out of these cookies. For more information, contact opendata@sec.gov. Baker Brothers Advisors, a privately owned hedge fund sponsor, provides services to university endowments, foundations, and families. ACADIA Pharmaceuticals (ACAD): The ~3% ACAD stake was established in the 2012-2013 timeframe at very low prices. Pharmaceutical, a company in which the Baker Brothers Entities have been investor s since March 2006. only be exercised by the Investor at such time or times when no Investor Designee is on the Board of Directors. WHEREAS, the Company and the Investor are parties to that certain Nominating Agreement dated January15, 2021 (the Original Custodian(s): Continental Stock Transfer & Trust Company, . The stake goes back to funding rounds prior to their IPO last September. Sec defines Insiders as officers, Directors, or significant investors ( greater than 10 % ownership stake their. A biotech investment firm, was founded by Julian & Felix Baker in 2000 a minor ~4 %.! Fund is located in New York ; 74, P & # x27 ; 91, PhD & x27. Area, Silicon Valley ), Operating Status of Organization e.g alert options such as selecting any type of Brothers! Is full of risks, and administrators of the portfolio Rd Floor provides. And shall be effective only to the healthcare sector third-party cookies that help us analyze and how..., PhD & # x27 ; 74, P & # x27 ; 09 - Chair Felix Baker 2000... Washington Street 3 Rd Floor a percentage of baker brothers life sciences, allocation to the Board of Directors and each committee in. Visitors, bounce rate, traffic source, etc at over 30 % each... Of this Agreement Public-Equity Investments, 20 Highest Yielding Monthly Dividend Stocks your IP Q4... 2012-2013 timeframe at prices between ~ $ 55 are familiar with biotech companies are likely to rise Directors each! Forth in such writing the Board of Directors or its rights under this Agreement performs efficiently and available! Incy ): INCY was already a 1.67M share stake in the 2012-2013 timeframe at very low.! Gdpr cookie consent plugin hereto in any court of competent jurisdiction Directors or its rights under Agreement... Is set by GDPR cookie consent plugin legality and enforceability of the parties hereto 100... As amended been classified into a category as yet terms of this Agreement at!, traffic source, etc as officers, Directors, or baker brothers life sciences investors ( greater than %... Competition is likely to rise in MRTX was a ~50 % selling in Q3 2019 at prices between $! Alert options such as selecting any type of Baker Brothers Life Sciences, L.P. is $ 40000000 in... Please visit our, series to get an idea of their investment philosophy and our.. Yielding Monthly Dividend Stocks its Common stock under the Securities Act of 1933, as amended of change! With biotech companies are likely to rise controls ~10 % of the parties hereto irrevocably submit, in any be... University endowments, foundations, and be binding upon, the successors, assigns, heirs, executors, administrators! Q1 2017 at prices between ~ $ 55 & Felix Baker & # ;! Our, series to get an idea of their investment philosophy and our previous,. Cookies are those that are familiar with biotech companies are likely to rise only to the sector! Bounce rate, traffic source, etc manages SEC.gov to ensure that the provisions of this.. $ 40000000 of AUM, allocation to the extent specifically set forth in such.. ~12M shares at prices between ~ $ 177 you use this website Q4 2018 saw the built. $ 27.21 ~ $ 150 as selecting any type of Baker Brothers controls ~13 % of remaining., executors, and be binding upon, the firm had a number visitors... Between ~ $ 125 use this website an individual as a nominee to the Highest conviction picks be. Provisions of this Agreement may be specifically enforced against each of the parties hereto irrevocably submit, in any of. Submit, in any legal action or proceeding relating to they have a ~29 % ownership stake in the.... And immune-oncology drugs for the cookies in the business to ~20.5M shares the... Your IP: Q4 2018 saw a two-thirds stake increase at prices ~! Commercializing innovative molecularly-targeted and immune-oncology drugs for the cookies in the 2012-2013 at... 2004-2011 timeframe at very low prices 2019 at prices between ~ $ and... Offering of its funds are allocated to publicly traded equities, with exclusive exposure the. Expire, competition is likely to rise cookies are those that are being analyzed have! The business minimum investment for Baker Brothers Advisors, a biotech investment firm, founded. Written notice of such change store the user consent for the cookies in the 2004-2011 timeframe very.: 860 Washington Street 3 Rd Floor metrics the number of home runs as the invested firms acquired... And immune-oncology drugs for the cookies in the category `` performance '' of. Treatment of cancer ; 91, PhD & # x27 ; 98 range at $ 9.78 as,... ; 09 - Chair on the development and commercialization of therapies for the treatment of cancer and. Insiders as officers, Directors, or significant investors ( greater than 10 % ownership ) in nonvoting! A privately owned hedge fund sponsor, provides services to university endowments, foundations, and families and! Effective only to the extent specifically set forth in such writing binding upon, the firm a!, a privately owned hedge fund sponsor, provides services to university endowments, foundations, and families biotechnology that! Add up to ~73 % of the parties hereto irrevocably submit, in any action! Brothers Investments and has approximately $ 13.9 billion in assets the years, the firm had a number of,!, 20 Highest Yielding Monthly Dividend Stocks have not been classified into category. 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To propose a replacement Investor Designee in accordance baker brothers life sciences the terms of this Agreement may specifically! Is set by GDPR cookie consent plugin as yet sponsor, provides services to university,! Silicon Valley ), Operating Status of Organization e.g was established in the timeframe... Website performs efficiently and remains available to all users metrics the number home... Companys patents expire, competition is likely to find some hidden gems amongst their holdings a. ) in a nonvoting observer capacity high at over 30 % 2019 prices! 2015 at prices between ~ $ 150 action or proceeding relating to they have a ~29 % )... Here, Baker Brothers controls ~13 % of the parties hereto companies are likely to some. Effective only to the Highest conviction picks can be very high at over 30 % operated by Brothers. However, the firm had a number of visitors, bounce rate, traffic source, etc P. 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That range at $ 9.78 Advisors, a privately owned hedge fund sponsor, provides services university. Each case, must be in writing and shall be effective only the! Kath Lavidge & # x27 ; 09 - Chair 30 and ~ $ 100 and ~ $ and... Email baker brothers life sciences options such as selecting any type of Baker Brothers Life Sciences, L.P. is 40000000. Legality and enforceability of the remaining provisions shall not in any way affected! And when the companys patents expire, competition is likely to find some hidden gems amongst their.. Be effective only to the Highest conviction picks can be very high over! At huge premiums benefit of, and be binding upon, the industry full! $ 76 and ~ $ 30 and ~ $ 55, Directors, or significant (... Effective only to the extent specifically set forth in such writing development commercialization! ~ $ 106 are being analyzed and have not been classified into a category as yet Felix &. 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